生体システムの多様性と合理的な有用物質生産への応用

（最終シンポジウム）

Diversity of Biosystems and Rational Production of Useful Substances

(Final Symposium)

主催　日本学術振興会　未来開拓学術研究推進事業研究
（複合領域）「生命科学と化学的手法の融合による新有用物質生産」研究推進委員会

---

［日時］　平成１４年１月１５日（火）９：３０〜１７：１５　（交流会１８：００〜２０：００）

［場所］　ぱるるプラザ京都

---

［プログラム］

9:30-9:35　Opening Remarks

Sakayu Shimizu (Kyoto University, Japan)

清水　昌（京都大学）

9:35-9:55　Creation of Nucleic Acid Duplexes Having an Artificially Designed Bent Structural Motif

Mitsuo Sekine (Tokyo Institute of Technology, Japan)

関根光雄（東工大院・生命理工）

9:55-10:15　Specific Microbial Protease Inhibitors Made from RNA: An in vitro Selection

Yo Kikuchi (Toyohashi University of Technology, Japan)

菊池　洋（豊橋技科大・工）

10:15-10:45　 The SATE Prodrug Approach: from Mono to Oligonucleotide Delivery

Jean-Louis Imbach (Montpellier II University, France)

10:45-11:05　Break

11:05-11:25　Design of New Artificial DNA with Four Hydrogen-Bonding Base-Pairs

Akira Matsuda (Hokkaido University, Japan)

松田　彰（北大院・薬）

11:25-11:45　From The Mechanisms of Action of Ribotoxins to The Cnstruction of a Highly Efficient Cell-Free Protein Synthesis System

Yaeta Endo (Ehime University, Japan)

遠藤弥重太（愛媛大・工）

11:45-12:05　Cell-Free Gene Expression System for Constructive Biology

Takuya Ueda (The University of Tokyo, Japan)

上田卓也（東大・新領域創成科学）

12:05-13:30　Lunch Break

13:30-14:00　Structure-Based Engineering and Directed Evolution of Enzymes for Organic Synthesis

Chi-Huey Wong (The Scripps Research Institute, USA)

14:00-14:20　Structure and Function of Prenyl Chain Elongating Enzymes

Tanetoshi Koyama (Tohoku University, Japan)

古山種俊（東北大・多元物質科学研）

14:20-14:50　New Strategies for Enantioselective Biotransformations Using Hydrolases

Uwe T. Bornscheuer (Ernst Moritz Arndt Universitaet Greifswald, Germany)

14:50-15:10　The Cathedral and The Bazaar; Architecture of Extracellular Signaling Systems in Streptomyces

Teruhiko Beppu (Nihon University, Japan)

別府輝彦（日大・生物資源科学）

15:10-15:40　Break

15:40-14:10　Creation of Protein/Enzyme Lineages with New Sequence Spaces by Functional Salvage Screen

Hak-Sung Kim (Korea Advanced Institute of Science and Technology, Korea)

16:10-16:30　Discovery and Modes of Action of Secondary Metabolites from Marine Sponges. Calyculin and Polytheonamide

Shigeki Matsunaga (The University of Tokyo, Japan)

松永茂樹（東大院・農学生命科学）

16:30-16:50　Molecular Analysis and Application of Microbial Secondary Metabolisms

Katsumi Kakinuma (Tokyo Institute of Technology, Japan)

柿沼勝己（東工大院・理工）

16:50-15:10　Anti-HIV Antibiotics That Block Viral Entry to Cells

Haruo Tanaka (Kitasato University, Japan)

田中晴雄（北里大・薬）

17:10-17:15　Closing Remarks

Teruhiko Beppu (Nihon University, Japan)

別府輝彦（日大・生物資源科学）

18:00-20:00　Mixer（交流会）

---